Integrin 6 1 is the Main Receptor for Vascular Laminins and Plays a Role in Platelet Adhesion , Activation and Arterial Thrombosis Running title :
نویسندگان
چکیده
UMR_S949, INSERM, Université de Strasbourg (UdS), Etablissement Français du SangAlsace, Strasbourg; UMR_S1109, INSERM, UdS, Strasbourg; UMR_7104, CNRS, UMR_S964, INSERM, UdS & Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch-Graffenstaden, France; Rudolf Virchow Center, University of Würzburg, Würzburg, Germany; UMR_S770, INSERM, Université Paris-Sud, Le Kremlin-Bicêtre, France * These authors contributed equally to this work.
منابع مشابه
Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis.
BACKGROUND Laminins are major components of basement membranes, well located to interact with platelets upon vascular injury. Laminin-111 (α1β1γ1) is known to support platelet adhesion but is absent from most blood vessels, which contain isoforms with the α2, α4, or α5 chain. Whether vascular laminins support platelet adhesion and activation and the significance of these interactions in hemosta...
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Platelet activation and adhesion to the site of vascular injury is a dynamic process comprising reversible and irreversible phases. Platelet adhesion typically occurs in a multi-step process similar to the selectin/integrin-mediated adhesion of neutrophils. This phenomenon is highly regulated and influenced by the cross-talk between platelets and injured endothelium. This cross-talk involves a ...
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Ferletta, M. 2002. The Laminins and their Receptors. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 688. 67 pp. Uppsala. ISBN 91-554-5239-6 Basement membranes are thin extracellular sheets that surround muscle, fat and peripheral nerve cells and underlay epithelial and endothelial cells. Laminins are one of the main pr...
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